منابع مشابه
Disabling multiple integrins from the inside out.
In the days before it became routine to knock out genes in mice, the identification of the genetic basis for rare immunodeficiencies in humans was often critical to establishing the physiological significance of a gene product. A prime example of the scientific utility of these immunodeficiences has been in the analysis of integrins, a family of αβ heterodimeric cell surface receptors that medi...
متن کاملVasodilator-stimulated phosphoprotein regulates inside-out signaling of beta2 integrins in neutrophils.
The monomeric GTPase Rap1 controls functional activation of beta2 integrins in leukocytes. In this article, we describe a novel mechanism by which the chemoattractant fMLP activates Rap1 and inside-out signaling of beta2 integrins. We found that fMLP-induced activation of Rap1 in human polymorphonuclear leukocytes or neutrophils and differentiated PLB-985 cells was blocked by inhibitors of the ...
متن کاملFunctional, Histomorphometrical and Immunohistochemical Assessment of Sciatic Nerve Regeneration through Inside-Out Vein Graft in Rat
Objective- Comprehensive functional, histomorphometrical and immunohistochemical assessment of sciatic nerve regeneration through an inside-out vein graft in rat. Design- Experimental in vivo study. Animals- Fifty- four healthy male White Albino rats. Procedures- The rats were divided into three experimental groups (n=18), randomly: Sham-operation (NC), Transected control (TC) and Inside-out ve...
متن کاملInside Out
I have alwayswanted to be adoctor.Manyaspects ofmedicine enthralled me: research, diagnosis, and the possibility of improving a patient’s quality of life, in particular.Walking the corridors of a hospital felt exhilarating. At 15 I had a volunteer position at the local hospital. Although my assignments were answering phones, directing visitors, and, my favorite, delivering goods topatients, I f...
متن کاملRadiation-induced cell signaling: inside-out and outside-in.
Exposure of tumor cells to clinically relevant doses of ionizing radiation causes DNA damage as well as mitochondria-dependent generation of reactive oxygen species. DNA damage causes activation of ataxia telangiectasia mutated and ataxia telangiectasia mutated and Rad3-related protein, which induce cell cycle checkpoints and also modulate the activation of prosurvival and proapoptotic signalin...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 1996
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.v781091